Clozapine Dose Planner

This tool has been developed to assist you in thinking about the pharmacokinetics of clozapine. The information here is synthesized from clinical research studies and may not be representative of an individual patient response.

This tool is not intended to influence prescribing practices but should be used to provide an estimate of what plasma level might be obtained, given the parameters of age, gender, weight, and smoking status.

Clinical decisions should be based upon your knowledge of the patient’s situation and history and the plasma level itself, not an estimate. Clozapine levels should be drawn in the morning 12 hours after the last dose. If there is a morning clozapine dose, it should be held until the level can be drawn.

Which of the following scenarios would you like to explore?(Required)

I would like to predict the clozapine level based on the clozapine dose, smoking status, sex, weight, and age

I would like to predict the clozapine dose that would be needed to achieve a clozapine level that I determine (e.g. 350 ng/mL) based on the patient’s smoking status, sex, weight, and age.

Smoker

Smoking

Non-Smoking

Sex

Male

Female

Please note, this tool was not developed to be used for transgender individuals.

Units

Weight (lbs)

Clozapine dose predictions may not be accurate for individuals with very low or very high body weight.

Weight (kg)

Clozapine dose predictions may not be accurate for individuals with very low or very high body weight.

Age

Clozapine Dose (FDA maximum 900 mg)

Clozapine Level (ng/mL)

Disclaimer: This Clozapine Dose Planner tool and the information it presents are not meant to serve as a guideline for individual patient management. It should not be considered as statement of the standard of care or inclusive of all considerations relevant to care. Any action suggested by this tool should not be used by a clinician without independent evaluation; ultimate treatment decisions must always be made by the treating clinician, including in light of each individual patient’s specific conditions and possible contraindications or dangers in use, applicable manufacturer product information, the psychiatric and medical evidence, recommendations of relevant authorities, other relevant clinical data, and diagnostic and treatment options available for such patient. APA provides the tool and all information on this site on an “as is” basis and makes no warranties, expressed or implied, regarding the tool, including that the information contained within it is free from error. APA assumes no responsibility and fully disclaims all liability for any injury or damage to persons or property arising out of or related to any use of this tool, including for any errors or omissions.