Despite advances in pharmacological and psychosocial interventions, many patients with schizophrenia continue to experience persistent symptoms, functional impairment, and reduced quality of life. This session will review evidence-based management strategies for treatment-resistant schizophrenia, including optimizing antipsychotic therapy, addressing adherence challenges, and evaluating augmentation. Dr. Christoph Correll will draw upon clinical trial data, meta-analyses, and real-world evidence to highlight practical approaches for improving long-term outcomes.