This clinical resource details the pharmacology and management of Novel Psychoactive Substances (NPS), specifically focusing on synthetic cathinones (bath salts) and synthetic cannabinoids (Spice or K-2). It provides a comprehensive guide to the physical and psychological signs of intoxication and withdrawal. This guide includes structured management protocols, emphasizing immediate medical triage, the use of benzodiazepines for agitation, and the potentially intensive antipsychotic treatment required for NPS-induced psychosis.