What long-acting injectable (LAI) antipsychotic medications are available in the U.S.?

See clinical tips available (linked below) on individual LAIs for more detailed information about what clinicians should know.

LAI Drug Name	FDA Indications *(Adult 18+ unless otherwise noted)**	Dosing Tips (frequency of administration, oral overlap)
*First Generation Antipsychotics*
Haldol Decanoate (haloperidol decanoate)	Schizophrenia	4 weeks
Prolixin Decanoate (fluphenazine decanoate)	Schizophrenia	2-6 weeks Overlap PO 4-8 weeks
*Second Generation Antipsychotics*
Abilify Asimtufii (aripiprazole LAI)	Schizophrenia Bipolar maintenance	8 weeks Overlap PO 2 weeks
Abilify Maintena (aripiprazole monohydrate LAI)	Schizophrenia Bipolar maintenance	4 weeks Overlap PO 2 weeks
Aristada (aripiprazole lauroxil LAI)	Schizophrenia	4 or 6 or 8 weeks Aristada Initio IM & PO 1 dose or Overlap PO 3 weeks
Aristada Initio (aripiprazole lauroxil LAI)	Initiation of Maintenance Aristada (aripiprazole lauroxil LAI) in Schizophrenia	Only for initiation of Aristada once Given with Aristada first injection
Invega Sustenna (paliperidone palmitate LAI)	Schizophrenia Schizoaffective Disorder	4 weeks Loading IM day 1 & day 8
Invega Hafyera (paliperidone palmitate 6-month LAI)	Schizophrenia	6 months; after adequately treated with INVEGA SUSTENNA for at least 4 months OR INVEGA TRINZA for at least one three-month cycle
Invega Trinza (paliperidone palmitate 12-week LAI)	Schizophrenia	12 weeks; after adequately treated with INVEGA SUSTENNA for at least four months, with the last 2 doses of INVEGA SUSTENNA at the same dosage strength
Perseris (risperidone subcutaneous LAI)	Schizophrenia	4 weeks Subcutaneous (SC)
Risperdal Consta (risperidone microspheres LAI)	Schizophrenia Bipolar I maintenance	2 weeks Overlap PO 3 weeks
Uzedy (risperidone subcutaneous LAI)	Schizophrenia	4 or 8 weeks
Zyprexa Relprevv (olanzapine LAI)	Schizophrenia	2 or 4 weeks Smoking status dosing considerations Risk: Post-injection delirium sedation syndrome (PDSS) – registry required

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